Clinical studies

Academic studies

Circumcision: Effect of dexamethasone in caudal block versus penile block on post-operative pain in paediatric circumcision

Study design: Prospective, monocentric, randomised clinical trial

The objective of this study is to determine whether dexamethasone prolongs the duration of the analgaesic effect in a penile block, as it does in a caudal block, in circumcisions.

Phase: Phase 4 study

Principle investigator: Dr Joris Goossens

Research Centre: Maria Middelares General Hospital

Cogenius study: Comparison of COnventional and cooled radiofrequency treatment of GENIcular nerves versUS a sham treatment in patients with chronic knee pain

Study design: Multicentre double-blinded, randomised, controlled clinical trial

To research the effect of both chilled and conventional (classical) radiofrequency (RF) treatment on individuals who have chronic knee pain and for whom conservative treatments have failed. The effect of this treatment will be compared with a sham procedure in terms of knee pain, knee function, quality of life, mental health and overall health care. Patients suffering from chronic knee pain caused by osteoarthrosis or persistent pain after a total knee replacement placement are eligible to participate and will be followed up for approximately two years as part of this study.

Principle investigator: Dr Pieter Vander Cruyssen

Principal: East Limburg Hospital

Research Centre: Maria Middelares General Hospital

Avalus European Registry: Data collection from the AVALUS biological aortic valve

SQuaD 4 Anaesthesia will provide support for the practical implementation of this study and the data collection.

Study design: Prospective, observational, multicentre study

This study aims to investigate the outcomes of aortic valve replacement with the AVALUS pericardial biological heart valve. This heart valve is also frequently used at Maria Middelares General Hospital for aortic valve replacements. This study will examine how patients fare up to one year post surgery. This is an observational study, with no additional interventions or examinations.

Principle investigator: Dr Koen Cathenis

Principal: Leuven University Hospital, Cardiac Surgery Department

Research Centre: Maria Middelares General Hospital

Targeted fluid therapy for DIEP flap breast reconstruction

Study design: Monocentric, randomised and controlled non-inferiority study

With this study, we aim to compare bounded fluid therapy, in which the administration of intravenous fluid is limited to a predetermined volume, with targeted fluid therapy, in which the administration of intravenous fluid is controlled based on a specific filling parameter determined by blood pressure. If necessary, additional assessment is initiated to increase blood pressure medication. This study helps us evaluate the impact of these fluid therapies on blood flow and swelling of the reconstructed breast.

Principle investigator: Dr Silvie Allaert

Research Centre: Maria Middelares General Hospital

Industrial studies

ESsCAPE study: Study to assess the efficacy and safety of trimodulin (BT588) in adult hospitalised subjects with severe community-acquired pneumonia (sCAP)

Study design: Randomised, placebo-controlled, double-blind, multi-centre and multi-national study

The aim of this study is to compare the efficacy and safety of trimodulin as an adjunct to standard treatment with placebo (combined with standard treatment) in adult hospitalised individuals with SCAP, who require invasive mechanical ventilation.

Sponsor: Biotest AG

Phase: Phase 3 study

Local principal investigator: Dr Jan Heerman